Znanstvenici su u kompozitni materijal za punjenje ugradili nanomaterijal koji ima antibakterijska svojstva. Ovaj novi materijal za punjenje može učinkovito spriječiti ponovnu pojavu zubnih šupljina uzrokovanih virulentnim bakterijama.
Karijes (zove zubni cavities or dental caries) is a very common and widespread bakterijski disease in school-going children and adults. Virulent bakterija kao mutans streptokok accumulate on the surface of the tooth and start to dissolve hard tissues. Once bakterija settle on the tooth surface, it leads to secondary (or recurrent) tooth decay at the edges of dental punjenje due to production of acid by cavity-causing bakterija which now reside in the interface of dental filling and the tooth. Tooth decay caused by bacteria is responsible for failure of dental restoration material affecting 100 million patients every year. Recurrent tooth cavities and decay leads to tooth extraction and root canal treatments.
Ranije su se za dentalne nadoknade koristile amalgamske plombe od metalnih legura. Ove plombe su imale nešto antibakterijski učinak, ali je imao i nedostatke čvrste boje, toksičnosti žive i nedostatka prianjanja na zub. Sada se kompozitne smole koriste u materijalima za restauraciju zuba, no nemaju antibakterijska svojstva što je veliki nedostatak. Također, postupno oslobađanje svih topljivih tvari iz smole utječe na njihova mehanička svojstva što rezultira poroznom ili slabom smolom. Mnogi ispitani kombinirani materijali vremenski su ograničeni i također mogu biti toksični prema susjednim tkivima, pogotovo zato što zahtijevaju visoke doze. Kompozitne plombe na bazi smole koje pokazuju aktivnost inhibicije bakterija mogu spriječiti razvoj raširenih oralnih bolesti poput karijesa.
U studiji objavljenoj 28. svibnja god Primijenjeni materijali i sučelja ACS-a, researchers describe a new enhanced material having intrinsic potent antibakterijski capabilities which can be used for novel dental fillings to prevent recurrent tooth decay. Same team of researchers had discovered in their earlier work that self-assembling building block Fmoc-pentafluro-L-phenylalanine-OH (Fmoc) has potent antibakterijski and also anti-inflammatory properties. And, it contains both functional and structural subparts. In the current study, researchers functionally incorporated Fmoc nanoassemblies inside resin-based dental composite material using novel methods developed by them.
Korištenje električnih romobila ističe antibakterijski capabilities of this new filling material was subsequently evaluated. Researchers also analysed its mechanical strength, optical properties and biocompatibility. When resin-based composites are added with antibacterial nano-assemblies it gets the ability to inhibit and hinder growth and viability of bakterija. The new material was non-toxic and the mechanical or optical properties of the nanaoassemblies remains unaffected by the integration. The antibacterial activity against bacterium S mutani zahtijevala vrlo nisku dozu novog materijala.
The current study demonstrates antibakterijski activity of Fmoc nanoassemblies and its functional incorporation into dental resin composite filling to develop a biocompatible resin composite amalgamated material. The new filling material is pleasant looking, mechanically rigid, has high purity, is inexpensive and can be easily embedded within resin-based filling materials.
***
{Izvorni istraživački rad možete pročitati klikom na vezu DOI koja se nalazi u nastavku na popisu citiranih izvora}
Izvor (i)
Schnaider, L. i sur. 2019. Poboljšani antibakterijski kompozitni materijali ugrađeni u nanomontažu. ACS primijenjeni materijali i sučelja. 11 (24). https://doi.org/10.1021/acsami.9b02839
